Endocrine Abstracts

Background: Pulmonary carcinoid (PC) tumors represent approximately 25% of neuroendocrine tumors (NETs) and about 2% of all lung cancers. Despite the relative prevalence of PCs compared to all NETs, there is only one FDA indicated therapy (everolimus). Since regulatory approvals stem from publications that are often initially presented at scientific meetings, we sought to determine the frequency of presentations including PCs at two major international NET and lung cancer meet...

Background: Metastatic neuroendocrine carcinomas (NECs) have a poor prognosis, and standard first-line chemotherapy combines etoposide (E) and platinum (P) has limited benefit. Currently, there is no standard second-line therapy. Irinotecan-based regimens have shown benefits; hence we explored nanoliposomal Irinotecan (nal-IRI) efficacy in this patient population.Methods: In this open-label, single-arm, multi-center Phase 2 study, advanced GEP or unknown...

Background: Peptide receptor radionuclide therapy (PRRT) with Lutetium-177 DOTATATE (LUTATHERA) is an effective treatment option for somatostatin receptor (SSTR) positive metastatic gastroenteropancreatic neuroendocrine tumors (NETs) and has also demonstrated antitumor activity in SSTR positive NETs from other primary sites. While the median progression free survival (mPFS) is around 29 months, there is a subset of patients who are refractory to PRRT and demonstrate progressio...